Step 2Next, vacuum the entire mattress surface with the upholstery attachment on your vacuum cleaner. Pay attention to seams and crevices, where dirt, dust, dead skin, and other icky stuff collect; switching to your vacuum’s crevice attachment can help get in deep.Our tests have found that a normal vacuum cleaner provides capable cleaning, but if you’re fastidious, consider investing in the Dyson V6 Mattress Handheld Vacuum, a $250 device designed specifically for the job. In a Consumer Reports at-home mattress test, we cleaned half of a foam Tempur-Pedic mattress with a top-rated canister vacuum and half with the Dyson handheld. The Dyson sucked up 3 grams of material, including dead skin cells that dust mites like to nosh on, compared with the 1 gram that our regular vacuum removed.Step 3Once you’re finished vacuuming, check for stains and spot treat them with an appropriate cleaner. An upholstery cleaner or enzyme-based pet-odor remover can do the job on many bodily fluids. You can also try a simple solution of 1 teaspoon mild dish detergent and 1 cup of warm water.